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Ye F, Chai W, Xie M, Yang M, Yu Y, Cao L, et al

doi: 10.1016/0003-2697(74)90459-x

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Santn-Mrquez et al., 2019), reduce beta-amyloid and tau production (Kim, 2021), increase brain derived neurotrophic factor (Kim et al., 2017), postsynaptic density protein 95, AMPA receptor 1 (GluA1), dendritic spine density (Zhang et al., 2017), and blood brain barrier integrity (Li et al., 2013)

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In the diet, lignans often occur as complex precursors (like secoisolariciresinol diglucoside in flax) that are metabolized by gut microbiota into bioactive forms (54)