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Larger particles, by contrast, benefit from prolonged circulation and enhanced accumulation at the tumor periphery, but their restricted penetration into deeper tissue regions remains a persistent limitation [33, 38, 40]

doi: 10.3168/JDS.2006-445 20 BonillaL.LuchiniD.DevillardE.HansenP

As continuous oversight becomes standard, execution maturity may become a key differentiator between organizations that merely observe trial risk and those that resolve it proactively

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