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Sequence: Ala-Glu-Asp-Gly (AEDG) Derived from pineal polypeptide epithalamin Investigated for telomere length, sleep architecture and lifespan in rodents Vladimir Khavinson's research group, St Petersburg 30+ years of preclinical data Sequence H-Ala-Glu-Asp-Gly-OH Molecular weight 390.35 g/mol Half-life Short systemic half-life

What separates high responders from moderate responders Post-hoc analyses of the SURMOUNT trials identified patterns in who responds most strongly to tirzepatide