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Given its role in metabolic regulation and potential effects on lifespan, MOTS-c has been proposed as a potential therapeutic target for a variety of conditions, including metabolic disorders, age-related diseases, and even cancer

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Pioneering this group is cisplatin, to exhibits proven pro-senescence effects [53]

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The resulting cell lysate was filtered through a 0.2-m filter and loaded onto a 5-mL HisTrap HP column (GE Healthcare/Cytiva) equilibrated in wash buffer (50 mM Tris-HCl pH 8.0, 500 mM NaCl, 1 mM TCEP, 25 mM imidazole)

In those cases, the daily intake of B12 isnt able to keep up with the B12 the body is using