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notably, BBB permeability determines which gut-derived factors can access the CNS parenchyma [24]

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Vascular endothelial growth factor increases and induces the translocation of glucose transporter-1 to the cell membrane at the BBB, which promotes angiogenesis and decreases the expression of inter-endothelial tight junction proteins, such as occludin and zonula occludens-1 [73], thus causing BBB leakage

Annals of Biomedical Engineering , 33 (9), 12701280

Benzenediol-berberine Hybrids: Multifunctional Agents for Alzheimer's Disease