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The gutkidney axis in chronic kidney diseases

8b), including the Ripk4Irf6 axis, which promotes keratinocyte differentiation downstream of Notch1 (refs

10.2047/jioh-08-06-09 38 KT.MC.SF.GL

G.KheirL

IGF-1 is produced predominantly in the liver in response to growth hormone stimulation, but it is also synthesized locally in many tissues where it exerts autocrine and paracrine effects