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As the world's population is aging, the prevalence of AD will increase dramatically such that by 2050 the number of people with AD in the U.S

Most people experience no adjustment phase at all

Mostly, pollen-allergic people show more clinical symptoms when they inhale airborne pollen, such as hay fever, infection of oral mucosa, skin, and cardiovascular and respiratory tract septicity

Despite the high immunosuppressive efficacy, its adverse effects, narrow therapeutic window and high intra- and interpatient variability (IPV) in pharmacokinetics require therapeutic drug monitoring (TDM), which makes treatment with Tac a major challenge for physicians

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