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ET Comedian John Candy died suddenly on a movie set in Durango, Mexico on March 4th, 1994 where he was filming what would become his final movie, Wagons East

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doi: 10.1007/s00018-010-0525-1

(2) Sarin exerts toxicity by irreversibly inhibiting acetylcholinesterase (AChE), resulting in accumulation of acetylcholine at cholinergic synapses and subsequent neuromuscular and respiratory dysfunction

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