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Similarly, knockout models of the glutamatecysteine ligase catalytic subunit ( Gclc ), thioredoxin reductase 2 ( Txnrd2 ), and glutaredoxin 3 ( Glrx3 ), which play crucial roles as antioxidants, also showed embryonic lethality during mid-gestation (E12.5E13.5) ( Loss of the other key antioxidant enzyme, superoxide dismutase ( Sod2 ), was shown to be peri- or postnatally lethal in mice

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