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It showed a dose-dependent relationship between cigarette consumption and symptom severity

In 1912, the brand was taken over by Liggett & Myers and production moved to Durham, North Carolina.[1] The brand was acquired by Philip Morris (now Altria) in 1999

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20 The global vaping surge The addiction potential of e-cigarettes within a broader epidemiological and public health framework illustrates in Figure 4 the rapid rise in global vaping prevalence, regional market expansion, and the steep trajectory of new users, particularly among youth in high-income countries

Toxicol Lett 205:279284 Schubert J, Luch A, Schulz TG (2013) Waterpipe smoking: analysis of the aromaprofile of flavored waterpipe tobaccos