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21 Furthermore, in individuals with multiple sclerosis who smoke, there is an increased frequency of GPR15 + CD4 + T cells exhibiting Th17-like characteristics, implicating GPR15 as a potential link between environmental exposure and autoimmune pathogenesis

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Basic physiology of pain and tobacco smoking Objectives of smoking cessation in patients with pain The primary objective of smoking cessation interventions in smoking patients is to alleviate their pain and associated limitations in activities of daily living (ADLs)