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Long-term exposure to nicotine, regardless of the delivery method, can lead to addiction and dependence

The lower levels significantly reduce biological impact, supporting reduced exposure and lower biological activity, but long-term harm reduction is not yet established

In 2002, after multiple lawsuits in the 1990s and early 2000s, the tobacco industry was ordered to release documents and memos to the public in the Legacy Tobacco Documents Library at the University of San Francisco