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Previous ICSS studies have observed that chronic exposure to drugs sensitizes the brain reward system, and in doing so lowers the stimulation threshold (expressed as a current intensity or stimulation frequency) 46 required for ICSS 47

Previously, the DOT ban on smoking had not defined what smoking was, and it was clarified to include e-cigarettes

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30, 1997, but key provisions did not commence until September 1998.[118] The law provided an outline for the delivery of stamps to tobacco wholesalers and others, along with such mandates as where the stamp should be placed on the cigarette pack (see Graphic 15)

According to the 2019 National Youth Tobacco Survey on e-cigarette use, more than 5 million U.S

All other authors have disclosed any potential conflicts of interests