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Their analysis of oral cells that expressed human papillomavirus proteins and were exposed to cigarette smoke pointed to an increase in levels of an enzyme associated with tumor progression and DNA damage ( image: wirestock/Freepik & NIH/Wikimedia Commons ) By Julia Moili | Agncia FAPESP Tobacco smoking and human papillomavirus (HPV) are both well-known risk factors for head and neck cancer, but there is ample evidence to show they can interact to increase still further the risk of contracting the disease, according to a study by scientists at the University of So Paulo (USP) in Brazil and the University of Chile