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Transl Res (2013) 161:8998

Nevertheless, to minimize any confounding effects from solvent interactions, the concentration of DMSO, known to disrupt membrane integrity, was maintained below 1% in all working solutions, in accordance with the guidelines of the Clinical and Laboratory Standards Institute and previous findings by Tuner et al

This process is very efficient in encapsulating the agent since core loadings of up to 80 wt

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Rotman M, Welling MM, Bunschoten A, de Backer ME, Rip J, Nabuurs RJ, et al