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Information on Cigarette Box Sizes, Customized Options, and Industry Trends Recent regulatory and market data show that cigarette box sizes are increasingly influenced by compliance and structural efficiency

daily [19], levels of nicotine dependence [38], the heaviness of smoking [39], or cumulative pack years [6], and biomarkers such as cotinine levels [40], suggesting a pharmacologic or neurobiological link between nicotine exposure and mood dysregulation

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Pharmacogenetics 10 , 105114 (2000)

But with the sharp increase in youth vaping between 2017 and 2019, the Tobacco 21 initiative started gaining more traction