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The metformin binding to plasma proteins is negligible and it is eliminated unmodified by active tubular secretion and glomerular filtration (Scheen, 1996), thus is contraindicated in patients with kidney failure ( Although the majority of cases of lactic acidosis occur in elderly patients with multiple comorbidities, cases have been documented in the absence of renal impairment

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Major wildfires in Europe are now starting earlier, becoming more frequent and harder to stop, and doing more damage

The GATS 2014 for Pakistan revealed that a higher proportion of female SLT users (28.2%) had attempted to quit in the past 12 months compared to male users (19%)