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Arctander doesnt have a lot of information on tobacco flowerin 1960 it was very rare indeed, and even rarer than it is today, apparently

All authors contributed to the article and approved the submitted version

It sustains repeated exposure to a mix of toxicants in cigarette smoke

2 Alongside the process of addiction, nicotine harms health by accelerating heart rate, reducing oxygen supply to body tissues, constricting blood vessels and raising blood pressure, which weakens organs, such as the heart, over time

19 The use of more than one drug at the same time, or type of drug consumed at the same time, is called polydrug use