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Furthermore, an increased risk of morbidity, mortality, and need for mechanical ventilator support has been reported among COVID-19-positive current and former smokers. In addition, a population-based study conducted in Israel found that never smokers were at a greater risk of testing positive for COVID-19, compared with current and former smokers, while an analysis of UK Biobank data found no association between smoking and COVID-19 positivity
However, the level of DNA adducts was significantly lower in the pancreas compared to the lung explaining, at least partially, why a higher level of DNA mutations is observed in the lung of humans and animals exposed to cigarette smoke compared to the pancreas (13)
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