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It has also been shown that cbNPs accumulate in antigen-presenting dendritic cells derived from emphysematous lung tissue of smokers [73] and that cigarette smoke triggers the NLRP3 inflammasome [63], which is again consistent with the observation that IL-1 levels are elevated in smokers lungs [19]

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Documentation supporting a withdrawal code should record the symptom cluster and onset relative to last use not just patient smokes. Remission coding follows the same rule as the rest of the block: the ICD-10-CM Official Guidelines, Section I.C.5.b.3 (FY2026 guidelines ), require the providers explicit documentation of remission before F17.2x1 codes are assigned

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