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The collagen remodeling cycle completes its first full pass, and the cumulative effect of new fiber synthesis becomes visible as improved firmness, reduced sagging in the lower face and neck, and a measurable difference in skin density

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The results obtained demonstrated that the use of ALA (600 mg/day) as an additional therapy to doxorubicin and paclitaxel induces a significant improvement in the peripheral sensory neuropathy grading (according to National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0) and in the FACT/GOG-Ntx-12 (12-item neurotoxicity questionnaire) total score