Both clinical and animal studies have demonstrated the blood pressure-lowering effects of certain fermented milk products containing these peptides (47)
In an animal-based study, no significant adverse effects were reported in dogs, who were administered up to 300 mg of glutathione per kg body weight every day for 26 weeks
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They found GSH concentrations of 3 mM or 10 mM were able to modify platelet aggregation, TxB2 production, and PDGF release by platelets
The claim holds water according to a 2019 meta-analysis, whose authors note that a berberine-silymarin complex can indeed produce "satisfactory results" in increasing berberine's bioavailability.43 The same meta-analysis examined the metabolic effects of combining berberine with silymarin
As with CYP2E1, there are substantial inter-ethnic differences in CYP2D6 across populations, ranging from complete loss of function or reduction in functional activity (2570% of the population, dependent on ethnic origin and geographical location) to extensive, ultra-rapid metabolisers (1.59.3% of the population) (see Table 3 in the supplementary data for a summary of the evidence) [17, 38]
