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Access this article Similar content being viewed by others Abbreviations -GCL: -glutamate cysteine ligase GGT: -glutamyl transferase BSO: L-buthionine-(S, R)-sulfoximine GPx: glutathione peroxidase GSH and GSSG: reduced and oxidized glutathione, respectively MAPK: mitogen-activated protein kinase miR: microRNA Nrf2: NF-E2-related factor 2 ROS: reactive oxygen species REFERENCES Scir, A., Cianfruglia, L., Minnelli, C., Bartolini, D., Torquato, P., Principato, G., Galli, F., and Armeni, T

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It is a mixture of four amino acid polymers that bind to myelin-specific autoantibodies to reduce autoreactivity and promote a predominant Th2 phenotype ( Long-term outcomes for up to seven years for relapsing MS patients enrolled in the Glatiramer Acetate Low-frequency Administration (GALA) study demonstrated a 0.26 adjusted annualized relapse rate in the early-start GA group (randomized to GA in the placebo-controlled trial) compared to 0.31 in the delayed start GA group (switched to GA in the open label phase), with a risk ratio of 0.83 (95% CI 0.700.99, p = 0.04) with no differences between the two groups in terms of EDSS (expanded disability status scale) progression ( Interferons vs